Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver
Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected the perfused rat liver as experimental system...
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Main Authors: | , , , , , , , , , |
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Format: | Book |
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Frontiers Media S.A.,
2018-02-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |