Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected the perfused rat liver as experimental system...

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Main Authors: Giulio Calza (Author), Elisabeth Nyberg (Author), Matias Mäkinen (Author), Rabah Soliymani (Author), Annunziata Cascone (Author), Dan Lindholm (Author), Emanuele Barborini (Author), Marc Baumann (Author), Maciej Lalowski (Author), Ove Eriksson (Author)
Format: Book
Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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