Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver

• 主要な著者: Giulio Calza (著者), Elisabeth Nyberg (著者), Matias Mäkinen (著者), Rabah Soliymani (著者), Annunziata Cascone (著者), Dan Lindholm (著者), Emanuele Barborini (著者), Marc Baumann (著者), Maciej Lalowski (著者), Ove Eriksson (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected the perfused rat liver as experimental system...