Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver

• Päätekijät: Giulio Calza (Tekijä), Elisabeth Nyberg (Tekijä), Matias Mäkinen (Tekijä), Rabah Soliymani (Tekijä), Annunziata Cascone (Tekijä), Dan Lindholm (Tekijä), Emanuele Barborini (Tekijä), Marc Baumann (Tekijä), Maciej Lalowski (Tekijä), Ove Eriksson (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected the perfused rat liver as experimental system...