The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in <i>Drosophila</i>

• Hlavní autoři: Ahmed M. Alsehli (Autor), Sifang Liao (Autor), Mohamed H. Al-Sabri (Autor), Lukas Vasionis (Autor), Archana Purohit (Autor), Neha Behare (Autor), Laura E. Clemensson (Autor), Michael J. Williams (Autor), Helgi B. Schiöth (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2022-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events. While sleep disturbances are recognized as a side-effect of statin treatment, the impact of statins on sleep is under debate. Using Drosophila,...