Natural alkaloid coptisine, isolated from Coptis chinensis, inhibits fungal growth by disrupting membranes and triggering apoptosis

• Autors principals: Xiao-Jun Zhong (Autor), Shu-Rong Liu (Autor), Chao-Wei Zhang (Autor), Yun-Shi Zhao (Autor), Aniqa Sayed (Autor), Muhammad Shahid Riaz Rajoka (Autor), Zhen-Dan He (Autor), Xun Song (Autor)
• Format: Llibre
• Publicat: Elsevier, 2024-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: To evaluate the antifungal activity of coptisine, isolated from Coptis chinensis, against Cryptococcus neoformans both in vitro and in vivo, along with investigating its underlying mechanism. Methods: Microbroth dilution assay and disk diffusion assay were used to evaluate the antifungal...