Natural alkaloid coptisine, isolated from Coptis chinensis, inhibits fungal growth by disrupting membranes and triggering apoptosis

• Main Authors: Xiao-Jun Zhong (Author), Shu-Rong Liu (Author), Chao-Wei Zhang (Author), Yun-Shi Zhao (Author), Aniqa Sayed (Author), Muhammad Shahid Riaz Rajoka (Author), Zhen-Dan He (Author), Xun Song (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To evaluate the antifungal activity of coptisine, isolated from Coptis chinensis, against Cryptococcus neoformans both in vitro and in vivo, along with investigating its underlying mechanism. Methods: Microbroth dilution assay and disk diffusion assay were used to evaluate the antifungal...