Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis

IntroductionEndothelin-1 (ET-1) regulates renal and vascular function, but the clinical utility of selective ETA receptor antagonists has been limited due to associated fluid retention. The mechanisms underlying fluid retention remain poorly understood but could be a consequence of changes in ET-1 b...

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Main Authors: K. Melissa Hallow (Author), Peter J. Greasley (Author), Hiddo J. L. Heerspink (Author), Hongtao Yu (Author)
Format: Book
Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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