Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis

• मुख्य लेखकों: K. Melissa Hallow (लेखक), Peter J. Greasley (लेखक), Hiddo J. L. Heerspink (लेखक), Hongtao Yu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

IntroductionEndothelin-1 (ET-1) regulates renal and vascular function, but the clinical utility of selective ETA receptor antagonists has been limited due to associated fluid retention. The mechanisms underlying fluid retention remain poorly understood but could be a consequence of changes in ET-1 b...