Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis
IntroductionEndothelin-1 (ET-1) regulates renal and vascular function, but the clinical utility of selective ETA receptor antagonists has been limited due to associated fluid retention. The mechanisms underlying fluid retention remain poorly understood but could be a consequence of changes in ET-1 b...
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Frontiers Media S.A.,
2024-11-01T00:00:00Z.
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