Reaching for the Stars in the Brain: Polymer-Mediated Gene Delivery to Human Astrocytes

• Main Authors: Chaitanya R. Joshi (Author), Vijay Raghavan (Author), Sivakumar Vijayaraghavalu (Author), Yue Gao (Author), Manju Saraswathy (Author), Vinod Labhasetwar (Author), Anuja Ghorpade (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Astrocytes, the "star-shaped" glial cells, are appealing gene-delivery targets to treat neurological diseases due to their diverse roles in brain homeostasis and disease. Cationic polymers have successfully delivered genes to mammalian cells and hence present a viable, non-immunogenic alte...