Reaching for the Stars in the Brain: Polymer-Mediated Gene Delivery to Human Astrocytes

• Autores principales: Chaitanya R. Joshi (Autor), Vijay Raghavan (Autor), Sivakumar Vijayaraghavalu (Autor), Yue Gao (Autor), Manju Saraswathy (Autor), Vinod Labhasetwar (Autor), Anuja Ghorpade (Autor)
• Formato: Libro
• Publicado: Elsevier, 2018-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Astrocytes, the "star-shaped" glial cells, are appealing gene-delivery targets to treat neurological diseases due to their diverse roles in brain homeostasis and disease. Cationic polymers have successfully delivered genes to mammalian cells and hence present a viable, non-immunogenic alte...