Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

• Main Authors: Manoranjenni Chetty (Author), Theresa Cain (Author), Janak Wedagedera (Author), Amin Rostami-Hodjegan (Author), Masoud Jamei (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Poor metabolisers of CYP2B6 (PM) require a lower dose of efavirenz because of serious adverse reactions resulting from the higher plasma concentrations associated with a standard dose. Treatment discontinuation is a common consequence in patients experiencing these adverse reactions. Such patients b...