Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz
Poor metabolisers of CYP2B6 (PM) require a lower dose of efavirenz because of serious adverse reactions resulting from the higher plasma concentrations associated with a standard dose. Treatment discontinuation is a common consequence in patients experiencing these adverse reactions. Such patients b...
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| Main Authors: | , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2018-03-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |