Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

• Autori principali: Manoranjenni Chetty (Autore), Theresa Cain (Autore), Janak Wedagedera (Autore), Amin Rostami-Hodjegan (Autore), Masoud Jamei (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Poor metabolisers of CYP2B6 (PM) require a lower dose of efavirenz because of serious adverse reactions resulting from the higher plasma concentrations associated with a standard dose. Treatment discontinuation is a common consequence in patients experiencing these adverse reactions. Such patients b...