Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population

• Main Authors: Elsner Holger A (Author), Schlegelberger Brigitte (Author), Seidemann Kathrin (Author), Rehe Klaus (Author), Cario Gunnar (Author), Mehles Andrea (Author), Schnakenberg Eckart (Author), Welte Karl H (Author), Schrappe Martin (Author), Stanulla Martin (Author)
• Formato: Livro
• Publicado em: BMC, 2005-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF. Two common polymorphisms (677C>T and 1...