Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)

• मुख्य लेखकों: Jana Kubackova (लेखक), Ondrej Holas (लेखक), Jarmila Zbytovska (लेखक), Barbora Vranikova (लेखक), Guanghong Zeng (लेखक), Petr Pavek (लेखक), Anette Mullertz (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Oligonucleotides (OND) represent a promising therapeutic approach. However, their instability and low intestinal permeability hamper oral bioavailability. Well-established for oral delivery, self-emulsifying drug delivery systems (SEDDS) can overcome the weakness of other delivery systems such as lo...