An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection.

• Main Authors: Lynn Soong (Author), Nicole L Mendell (Author), Juan P Olano (Author), Dedeke Rockx-Brouwer (Author), Guang Xu (Author), Yenny Goez-Rivillas (Author), Claire Drom (Author), Thomas R Shelite (Author), Gustavo Valbuena (Author), David H Walker (Author), Donald H Bouyer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in animal models have utilized...