An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection.

• Hoofdauteurs: Lynn Soong (Auteur), Nicole L Mendell (Auteur), Juan P Olano (Auteur), Dedeke Rockx-Brouwer (Auteur), Guang Xu (Auteur), Yenny Goez-Rivillas (Auteur), Claire Drom (Auteur), Thomas R Shelite (Auteur), Gustavo Valbuena (Auteur), David H Walker (Auteur), Donald H Bouyer (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in animal models have utilized...