A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

• Главные авторы: Kirill Zhudenkov (Автор), Sergey Gavrilov (Автор), Alina Sofronova (Автор), Oleg Stepanov (Автор), Nataliya Kudryashova (Автор), Gabriel Helmlinger (Автор), Kirill Peskov (Автор)
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• Опубликовано: Wiley, 2022-04-01T00:00:00Z.
• Предметы: article
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Abstract Clinical trials investigate treatment endpoints that usually include measurements of pharmacodynamic and efficacy biomarkers in early‐phase studies and patient‐reported outcomes as well as event risks or rates in late‐phase studies. In recent years, a systematic trend in clinical trial data...