A workflow for the joint modeling of longitudinal and event data in the development of therapeutics: Tools, statistical methods, and diagnostics

• Main Authors: Kirill Zhudenkov (Author), Sergey Gavrilov (Author), Alina Sofronova (Author), Oleg Stepanov (Author), Nataliya Kudryashova (Author), Gabriel Helmlinger (Author), Kirill Peskov (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical trials investigate treatment endpoints that usually include measurements of pharmacodynamic and efficacy biomarkers in early‐phase studies and patient‐reported outcomes as well as event risks or rates in late‐phase studies. In recent years, a systematic trend in clinical trial data...