Presence of GABAB Receptors Forming Heterodimers With GABAB1 and GABAB2 Subunits in Human Lower Esophageal Sphincter

• Main Authors: Yasuhiro Torashima (Author), Yasuhito Uezono (Author), Masato Kanaide (Author), Yuko Ando (Author), Akihito Enjoji (Author), Takashi Kanematsu (Author), Kohtaro Taniyama (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Baclofen, a GABAB-receptor (GABABR) agonist has been proposed to be useful as therapeutic agent for the management of gastro-esophageal reflux disease, but whether the compound acts directly at the lower esophageal sphincter (LES) remains to be elucidated. We performed the present study to assess th...