Presence of GABAB Receptors Forming Heterodimers With GABAB1 and GABAB2 Subunits in Human Lower Esophageal Sphincter

• Egile Nagusiak: Yasuhiro Torashima (Egilea), Yasuhito Uezono (Egilea), Masato Kanaide (Egilea), Yuko Ando (Egilea), Akihito Enjoji (Egilea), Takashi Kanematsu (Egilea), Kohtaro Taniyama (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2009-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Baclofen, a GABAB-receptor (GABABR) agonist has been proposed to be useful as therapeutic agent for the management of gastro-esophageal reflux disease, but whether the compound acts directly at the lower esophageal sphincter (LES) remains to be elucidated. We performed the present study to assess th...