PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

• Главные авторы: Prakash Lingasamy (Автор), Kristina Põšnograjeva (Автор), Sergei Kopanchuk (Автор), Allan Tobi (Автор), Ago Rinken (Автор), Ignacio J. General (Автор), Eliana K. Asciutto (Автор), Tambet Teesalu (Автор)
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• Опубликовано: MDPI AG, 2021-11-01T00:00:00Z.
• Предметы: article
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Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors F...