PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

• Autors principals: Prakash Lingasamy (Autor), Kristina Põšnograjeva (Autor), Sergei Kopanchuk (Autor), Allan Tobi (Autor), Ago Rinken (Autor), Ignacio J. General (Autor), Eliana K. Asciutto (Autor), Tambet Teesalu (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2021-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors F...