PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

• Main Authors: Prakash Lingasamy (Author), Kristina Põšnograjeva (Author), Sergei Kopanchuk (Author), Allan Tobi (Author), Ago Rinken (Author), Ignacio J. General (Author), Eliana K. Asciutto (Author), Tambet Teesalu (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors F...