Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

• Main Authors: Lijian Zhang (Author), Kang Tian (Author), Yongqiang Li (Author), Lei Lei (Author), Aifang Qin (Author), Lijuan Zhang (Author), Hongrui Song (Author), Lianchao Huo (Author), Lijing Zhang (Author), Xiaofeng Jin (Author), Zhufang Shen (Author), Zhiqiang Feng (Author)
• Format: Book
• Published: Elsevier, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel phenyl-urea derivatives which can simultaneously activate glucokinase (GK) and peroxisome proliferator-activated receptor γ (PPARγ) was designed and prepared, and their activation of GK and PPARγ was evaluated. The structure-activity relationships of these compounds are also descri...