Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

• Главные авторы: Lijian Zhang (Автор), Kang Tian (Автор), Yongqiang Li (Автор), Lei Lei (Автор), Aifang Qin (Автор), Lijuan Zhang (Автор), Hongrui Song (Автор), Lianchao Huo (Автор), Lijing Zhang (Автор), Xiaofeng Jin (Автор), Zhufang Shen (Автор), Zhiqiang Feng (Автор)
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• Опубликовано: Elsevier, 2012-12-01T00:00:00Z.
• Предметы: article
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A series of novel phenyl-urea derivatives which can simultaneously activate glucokinase (GK) and peroxisome proliferator-activated receptor γ (PPARγ) was designed and prepared, and their activation of GK and PPARγ was evaluated. The structure-activity relationships of these compounds are also descri...