Novel phenyl-urea derivatives as dual-target ligands that can activate both GK and PPARγ

• প্রধান লেখক: Lijian Zhang (লেখক), Kang Tian (লেখক), Yongqiang Li (লেখক), Lei Lei (লেখক), Aifang Qin (লেখক), Lijuan Zhang (লেখক), Hongrui Song (লেখক), Lianchao Huo (লেখক), Lijing Zhang (লেখক), Xiaofeng Jin (লেখক), Zhufang Shen (লেখক), Zhiqiang Feng (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2012-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A series of novel phenyl-urea derivatives which can simultaneously activate glucokinase (GK) and peroxisome proliferator-activated receptor γ (PPARγ) was designed and prepared, and their activation of GK and PPARγ was evaluated. The structure-activity relationships of these compounds are also descri...