Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II

• Main Authors: Hahner Stefanie (Author), Reisch Nicole (Author), Penna-Martinez Marissa (Author), Meyer Gesine (Author), Willenberg Holger S (Author), Kahles Heinrich (Author), Lange Britta (Author), Ramos-Lopez Elizabeth (Author), Seissler Jürgen (Author), Badenhoop Klaus (Author)
• Format: Book
• Published: BMC, 2008-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Polymorphisms within the insulin gene can influence insulin expression in the pancreas and especially in the thymus, where self-antigens are processed, shaping the T cell repertoire into selftolerance, a process that protects from β-...