In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models

• Main Authors: Yu Liu (Author), Fujin Yang (Author), Linglin Feng (Author), Long Yang (Author), Lingyun Chen (Author), Gang Wei (Author), Weiyue Lu (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188 (GEL1, relative hydrophobic) or 6% p...