In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models

• Päätekijät: Yu Liu (Tekijä), Fujin Yang (Tekijä), Linglin Feng (Tekijä), Long Yang (Tekijä), Lingyun Chen (Tekijä), Gang Wei (Tekijä), Weiyue Lu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2017-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188 (GEL1, relative hydrophobic) or 6% p...