Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain

• मुख्य लेखकों: Fangjin Huang (लेखक), Hisashi Tanaka (लेखक), Beatrice S. Knudsen (लेखक), Joanne K. Rutgers (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Mutations in the exonuclease domain of POLE, a DNA polymerase associated with DNA replication and repair, lead to cancers with ultra-high mutation rates. Most studies focus on intestinal and uterine cancers with POLE mutations. These cancers exhibit a significant immune cell infi...