Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain
Abstract Background Mutations in the exonuclease domain of POLE, a DNA polymerase associated with DNA replication and repair, lead to cancers with ultra-high mutation rates. Most studies focus on intestinal and uterine cancers with POLE mutations. These cancers exhibit a significant immune cell infi...
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| Main Authors: | , , , |
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| Format: | Book |
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BMC,
2020-08-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |