Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain

• Asıl Yazarlar: Fangjin Huang (Yazar), Hisashi Tanaka (Yazar), Beatrice S. Knudsen (Yazar), Joanne K. Rutgers (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: BMC, 2020-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Background Mutations in the exonuclease domain of POLE, a DNA polymerase associated with DNA replication and repair, lead to cancers with ultra-high mutation rates. Most studies focus on intestinal and uterine cancers with POLE mutations. These cancers exhibit a significant immune cell infi...