Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major.

• Main Authors: Jennifer Timm (Author), Cristina Bosch-Navarrete (Author), Eliseo Recio (Author), Joanne E Nettleship (Author), Heather Rada (Author), Dolores González-Pacanowska (Author), Keith S Wilson (Author)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L. major Type II TK (LmTK) has been previously shown to be important for i...