Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major.

• Главные авторы: Jennifer Timm (Автор), Cristina Bosch-Navarrete (Автор), Eliseo Recio (Автор), Joanne E Nettleship (Автор), Heather Rada (Автор), Dolores González-Pacanowska (Автор), Keith S Wilson (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Предметы: article
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Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L. major Type II TK (LmTK) has been previously shown to be important for i...