Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales

• Главные авторы: Andrey D. Bondarev (Автор), Jörgen Jonsson (Автор), Vladimir N. Chubarev (Автор), Vadim V. Tarasov (Автор), Francisco Alejandro Lagunas-Rangel (Автор), Helgi B. Schiöth (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2024-11-01T00:00:00Z.
• Предметы: article
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The nucleic acid topoisomerases (TOP) are an evolutionary conserved mechanism to solve topological problems within DNA and RNA that have been historically well-established as a chemotherapeutic target. During investigation of trends within clinical trials, we have identified a very high number of cl...