In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation

• Main Authors: Seyed Mehdi Sajjadi (Author), Hamzeh Rahimi (Author), Saeed Mohammadi (Author), Mohammad Faranoush (Author), Hasan Mirzahoseini (Author), Gholamreza Toogeh (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection...