In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation

• Váldodahkkit: Seyed Mehdi Sajjadi (Dahkki), Hamzeh Rahimi (Dahkki), Saeed Mohammadi (Dahkki), Mohammad Faranoush (Dahkki), Hasan Mirzahoseini (Dahkki), Gholamreza Toogeh (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection...