DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients

• المؤلفون الرئيسيون: Weiguang Gu (مؤلف), Wenya Zhuang (مؤلف), Mengxia Zhuang (مؤلف), Minhong He (مؤلف), Zhihua Li (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2023-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background DNA damage response and repair (DDR) genes are crucial for maintaining the integrity of the genome. This study aims to explore the correlation of DDR gene mutations with TMB, clinical characteristics, and outcomes to platinum-based chemotherapy and platinum-based chemotherapy/imm...