Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS

• Main Authors: Chengyi Zuo (Author), Jingwei Zhou (Author), Sumin Bian (Author), Qing Zhang (Author), Yutian Lei (Author), Yuan Shen (Author), Zhiwei Chen (Author), Peijun Ye (Author), Leying Shi (Author), Mao Mu (Author), Jia-Huan Qu (Author), Zhengjin Jiang (Author), Qiqin Wang (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dynamic tracking analysis of monoclonal antibodies (mAbs) biotransformation in vivo is crucial, as certain modifications could inactivate the protein and reduce drug efficacy. However, a particular challenge (i.e. immune recognition deficiencies) in biotransformation studies may arise when modificat...