Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS

• Үндсэн зохиолчид: Chengyi Zuo (Зохиогч), Jingwei Zhou (Зохиогч), Sumin Bian (Зохиогч), Qing Zhang (Зохиогч), Yutian Lei (Зохиогч), Yuan Shen (Зохиогч), Zhiwei Chen (Зохиогч), Peijun Ye (Зохиогч), Leying Shi (Зохиогч), Mao Mu (Зохиогч), Jia-Huan Qu (Зохиогч), Zhengjin Jiang (Зохиогч), Qiqin Wang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2024-11-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Dynamic tracking analysis of monoclonal antibodies (mAbs) biotransformation in vivo is crucial, as certain modifications could inactivate the protein and reduce drug efficacy. However, a particular challenge (i.e. immune recognition deficiencies) in biotransformation studies may arise when modificat...