Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification

• Main Authors: Ruby Lieshout (Author), Alessandra V. S. Faria (Author), Maikel P. Peppelenbosch (Author), Luc J. W. van der Laan (Author), Monique M. A. Verstegen (Author), Gwenny M. Fuhler (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular signaling have changed the treatment paradigm of can...