Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...

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Main Authors: Mitsuhiro Machitani (Author), Fuminori Sakurai (Author), Keisaku Wakabayashi (Author), Kosuke Takayama (Author), Masashi Tachibana (Author), Hiroyuki Mizuguchi (Author)
Format: Book
Published: Elsevier, 2017-03-01T00:00:00Z.
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