Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

• Κύριοι συγγραφείς: Mitsuhiro Machitani (Συγγραφέας), Fuminori Sakurai (Συγγραφέας), Keisaku Wakabayashi (Συγγραφέας), Kosuke Takayama (Συγγραφέας), Masashi Tachibana (Συγγραφέας), Hiroyuki Mizuguchi (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2017-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...