Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

• Päätekijät: Mitsuhiro Machitani (Tekijä), Fuminori Sakurai (Tekijä), Keisaku Wakabayashi (Tekijä), Kosuke Takayama (Tekijä), Masashi Tachibana (Tekijä), Hiroyuki Mizuguchi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2017-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...