Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

• Main Authors: Guy Caljon (Author), Benoît Stijlemans (Author), Dirk Saerens (Author), Jan Van Den Abbeele (Author), Serge Muyldermans (Author), Stefan Magez (Author), Patrick De Baetselier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites. The anti-trypanosomal activity relies on perturbing the highly active recycling of the Variant-specific Surfac...