Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

• Hoofdauteurs: Guy Caljon (Auteur), Benoît Stijlemans (Auteur), Dirk Saerens (Auteur), Jan Van Den Abbeele (Auteur), Serge Muyldermans (Auteur), Stefan Magez (Auteur), Patrick De Baetselier (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND: The discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites. The anti-trypanosomal activity relies on perturbing the highly active recycling of the Variant-specific Surfac...