Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

• Hauptverfasser: Guy Caljon (Verfasst von), Benoît Stijlemans (Verfasst von), Dirk Saerens (Verfasst von), Jan Van Den Abbeele (Verfasst von), Serge Muyldermans (Verfasst von), Stefan Magez (Verfasst von), Patrick De Baetselier (Verfasst von)
• Format: Buch
• Veröffentlicht: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BACKGROUND: The discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites. The anti-trypanosomal activity relies on perturbing the highly active recycling of the Variant-specific Surfac...