Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

• Main Authors: Jorge Franco (Author), Francesco Piacente (Author), Melanie Walter (Author), Simone Fratta (Author), Moustafa Ghanem (Author), Andrea Benzi (Author), Irene Caffa (Author), Alexander V. Kurkin (Author), Andrea Altieri (Author), Patrick Herr (Author), Macarena Martínez-Bailén (Author), Inmaculada Robina (Author), Santina Bruzzone (Author), Alessio Nencioni (Author), Alberto Del Rio (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NAPRT, the rate-limiting enzyme of the Preiss-Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resistance to NAMPT inhibition in several tumor types wh...