Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

• Автори: Jorge Franco (Автор), Francesco Piacente (Автор), Melanie Walter (Автор), Simone Fratta (Автор), Moustafa Ghanem (Автор), Andrea Benzi (Автор), Irene Caffa (Автор), Alexander V. Kurkin (Автор), Andrea Altieri (Автор), Patrick Herr (Автор), Macarena Martínez-Bailén (Автор), Inmaculada Robina (Автор), Santina Bruzzone (Автор), Alessio Nencioni (Автор), Alberto Del Rio (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

NAPRT, the rate-limiting enzyme of the Preiss-Handler NAD biosynthetic pathway, has emerged as a key biomarker for the clinical success of NAMPT inhibitors in cancer treatment. Previous studies found that high protein levels of NAPRT conferred resistance to NAMPT inhibition in several tumor types wh...