Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs

• 主要な著者: Sabina Janciauskiene (著者), Srinu Tumpara (著者), Nils Helge Schebb (著者), Falk F. R. Buettner (著者), Malwina Mainka (著者), Kokilavani Sivaraman (著者), Stephan Immenschuh (著者), Veronika Grau (著者), Tobias Welte (著者), Beata Olejnicka (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulatin...