Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs

• Main Authors: Sabina Janciauskiene (Author), Srinu Tumpara (Author), Nils Helge Schebb (Author), Falk F. R. Buettner (Author), Malwina Mainka (Author), Kokilavani Sivaraman (Author), Stephan Immenschuh (Author), Veronika Grau (Author), Tobias Welte (Author), Beata Olejnicka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulatin...