Current Status of Oligonucleotide-Based Protein Degraders

• Main Authors: Po-Chang Shih (Author), Miyako Naganuma (Author), Yosuke Demizu (Author), Mikihiko Naito (Author)
• 格式: 图书
• 出版: MDPI AG, 2023-02-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Transcription factors (TFs) and RNA-binding proteins (RBPs) have long been considered undruggable, mainly because they lack ligand-binding sites and are equipped with flat and narrow protein surfaces. Protein-specific oligonucleotides have been harnessed to target these proteins with some satisfacto...