Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

• मुख्य लेखकों: Ahmed A. Al-Karmalawy (लेखक), Dalia S. El-Gamil (लेखक), Rabeh El-Shesheny (लेखक), Marwa Sharaky (लेखक), Radwan Alnajjar (लेखक), Omnia Kutkat (लेखक), Yassmin Moatasim (लेखक), Mohamed Elagawany (लेखक), Sara T. Al-Rashood (लेखक), Faizah A. Binjubair (लेखक), Wagdy M. Eldehna (लेखक), Ayman M. Noreddin (लेखक), Mohamed Y. Zakaria (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a-3g) in an attempt to improve their biological availability and antiviral activity. Next, both cytotoxicity and anti-SARS-CoV-2 activities of the examined compounds loaded EMLs (F3...