Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

• Main Authors: Ahmed A. Al-Karmalawy (Author), Dalia S. El-Gamil (Author), Rabeh El-Shesheny (Author), Marwa Sharaky (Author), Radwan Alnajjar (Author), Omnia Kutkat (Author), Yassmin Moatasim (Author), Mohamed Elagawany (Author), Sara T. Al-Rashood (Author), Faizah A. Binjubair (Author), Wagdy M. Eldehna (Author), Ayman M. Noreddin (Author), Mohamed Y. Zakaria (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a-3g) in an attempt to improve their biological availability and antiviral activity. Next, both cytotoxicity and anti-SARS-CoV-2 activities of the examined compounds loaded EMLs (F3...