Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

• Hoofdauteurs: Ahmed A. Al-Karmalawy (Auteur), Dalia S. El-Gamil (Auteur), Rabeh El-Shesheny (Auteur), Marwa Sharaky (Auteur), Radwan Alnajjar (Auteur), Omnia Kutkat (Auteur), Yassmin Moatasim (Auteur), Mohamed Elagawany (Auteur), Sara T. Al-Rashood (Auteur), Faizah A. Binjubair (Auteur), Wagdy M. Eldehna (Auteur), Ayman M. Noreddin (Auteur), Mohamed Y. Zakaria (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a-3g) in an attempt to improve their biological availability and antiviral activity. Next, both cytotoxicity and anti-SARS-CoV-2 activities of the examined compounds loaded EMLs (F3...