Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

• Autori principali: Ahmed A. Al-Karmalawy (Autore), Dalia S. El-Gamil (Autore), Rabeh El-Shesheny (Autore), Marwa Sharaky (Autore), Radwan Alnajjar (Autore), Omnia Kutkat (Autore), Yassmin Moatasim (Autore), Mohamed Elagawany (Autore), Sara T. Al-Rashood (Autore), Faizah A. Binjubair (Autore), Wagdy M. Eldehna (Autore), Ayman M. Noreddin (Autore), Mohamed Y. Zakaria (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a-3g) in an attempt to improve their biological availability and antiviral activity. Next, both cytotoxicity and anti-SARS-CoV-2 activities of the examined compounds loaded EMLs (F3...