Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model

• Main Authors: Masakatsu Takanashi (Author), Katsuko Sudo (Author), Shinobu Ueda (Author), Shin-Ichiro Ohno (Author), Yuko Yamada (Author), Yasuhiro Osakabe (Author), Hiroshi Goto (Author), Yoshimichi Matsunaga (Author), Akio Ishikawa (Author), Yoshihiko Usui (Author), Masahiko Kuroda (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA interference (RNAi) has become a powerful tool for suppressing gene expression in vitro and in vivo. A great deal of evidence has demonstrated the potential for the use of synthetic small interfering RNAs (siRNAs) as therapeutic agents. However, the application of siRNA to clinical medicine is s...