Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

• मुख्य लेखकों: Lun-Fei Liu (लेखक), Ji-Su Chen (लेखक), Ji-Yang Shen (लेखक), Ting-Ting Dou (लेखक), Jiong Zhou (लेखक), Sui-Qing Cai (लेखक), Min Zheng (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human s...