Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

• Main Authors: Lun-Fei Liu (Author), Ji-Su Chen (Author), Ji-Yang Shen (Author), Ting-Ting Dou (Author), Jiong Zhou (Author), Sui-Qing Cai (Author), Min Zheng (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human s...