Ustekinumab treats psoriasis by suppressing RORC and T-box but its suppression of GATA restrains its efficacy

• Hoofdauteurs: Lun-Fei Liu (Auteur), Ji-Su Chen (Auteur), Ji-Yang Shen (Auteur), Ting-Ting Dou (Auteur), Jiong Zhou (Auteur), Sui-Qing Cai (Auteur), Min Zheng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Psoriasis is a T-cell mediated disease that involves IL-23/Th17 and IL-12/Th1 axes. Ustekinumab, a fully human monoclonal antibody targeting the p40 subunit of both IL-12 and IL-23, has proven to be efficient and safe for treating patients with psoriasis. Yet, there have been no reports with human s...